| CAS
NO. |
1492-18-8 |
|
| EINECS NO. |
216-082-8 |
| FORMULA |
C20H21N7O7·Ca· 5H2O |
| MOL
WT. |
601.58 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SMILES |
|
| SYNONYMS |
Calcium folinate; 5-HCO-H4PteGlu;
Calcium Leucovorin; |
|
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid,
Calcium salt; Citrovorum factor; Folinic acid, calcium salt; Leucosar; Leucovorin
Citrovorum;
N-(4-(((2-Amino-5-formyl- 1,4,5,6,7,8- hexahydro-4-oxo-6-pteridinyl)methyl)
amino)benzoyl)-L- glutamic
acid, calcium salt;
N-(p-(((2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl) methyl)amino)benzoyl)
glutamic
acid, calcium salt; Folinato calcico;
Folinate de calcium; |
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
yellow
crystalline
powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. Hygroscopic,
light sensitive. |
|
APPLICATIONS
|
|
Folinic acid, chemically reduced derivative of folic acid
(5-formyl-5,6,7,8-tetrahydrofolate), acts as a coenzyme carrier in certain
folate-mediated reactions but does not require dihydrofolate reductase activity.
Thus, it is used as a calcium salt to counteract the toxic effects of folic acid
antagonists (e.g., methotrexate) and for treatment of megaloblastic anemias;
administered intramuscularly. Leucovorin is also used in combination
with fluorouracil to treat cancer of the colon. The chemical designation is
N-(4-(((2-Amino-5-formyl-1,4,5,6, 7,8- hexahydro- 4-oxo-6- pteridinyl) methyl)
amino) benzoyl)-L-glutamic
acid, calcium salt (1:1). |
| SALES
SPECIFICATION (USP24) |
|
APPEARANCE
|
yellow crystalline
powder |
|
IDENTIFICATION
|
Complies
|
|
ASSAY |
95.0%
- 105.0% |
|
WATER
|
17.0%
max
|
|
HEAVY METALS |
10ppm
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard Symbols: XN, Risk Phrases: 36/37/38-42/43, Safety Phrases:
26-36 |